H2N2V1, Main, Exploration, bibRecord, 000B94

Virulence determinants of pandemic influenza viruses

Identifieur interne : 000B94 ( Main/Exploration ); précédent : 000B93; suivant : 000B95

Virulence determinants of pandemic influenza viruses

Auteurs : Donna M. Tscherne ; Adolfo García-Sastre

Source :

The Journal of Clinical Investigation [ 0021-9738 ] ; 2011.

RBID : PMC:3007163

Abstract

Influenza A viruses cause recurrent, seasonal epidemics and occasional global pandemics with devastating levels of morbidity and mortality. The ability of influenza A viruses to adapt to various hosts and undergo reassortment events ensures constant generation of new strains with unpredictable degrees of pathogenicity, transmissibility, and pandemic potential. Currently, the combination of factors that drives the emergence of pandemic influenza is unclear, making it impossible to foresee the details of a future outbreak. Identification and characterization of influenza A virus virulence determinants may provide insight into genotypic signatures of pathogenicity as well as a more thorough understanding of the factors that give rise to pandemics.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3007163

DOI: 10.1172/JCI44947
PubMed: 21206092
PubMed Central: 3007163

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p>Influenza A viruses cause recurrent, seasonal epidemics and occasional global
               pandemics with devastating levels of morbidity and mortality. The ability of
               influenza A viruses to adapt to various hosts and undergo reassortment events ensures
               constant generation of new strains with unpredictable degrees of pathogenicity,
               transmissibility, and pandemic potential. Currently, the combination of factors that
               drives the emergence of pandemic influenza is unclear, making it impossible to
               foresee the details of a future outbreak. Identification and characterization of
               influenza A virus virulence determinants may provide insight into genotypic
               signatures of pathogenicity as well as a more thorough understanding of the factors
               that give rise to pandemics.</p>
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Virulence determinants of pandemic influenza viruses

Virulence determinants of pandemic influenza viruses

Source :

Abstract

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